Teleconsultation report, Clinic for Gynecology

Date: 2023-02-06 Institution: University Hospital Freiburg, Germany Type: Second opinion
Source file (Google Drive, docs_eng/): TK_Taran_Zherlitsyna, Anastasiia_43851462_Feb 2022.docx
Note: File name says Feb 2022; the letter reports the teleconsultation of 6 February 2023.

Links: English translation on Google Drive [hosted copy] (TK_Taran_Zherlitsyna, Anastasiia_43851462_Feb 2022.docx) (German original (on this site) · Drive backup [hosted copy])

UNIVERSITY HOSPITAL FREIBURG

Clinic for Gynecology Hugstetter Straße 55, D-79106 Freiburg

ZHERLITSYNA, Anastasiia *25.04.1976

Breisacher Str. 86b, 79110 Freiburg

PIZ 43851462

Dear Mrs. ZHERLITSYNA,

We report on your teleconsultation of February 6th, 2023.

Diagnosis:

Metastatic leiomyosarcoma (hepatic, peritoneal) ED 08/2022

Status post first-line therapy with 4 cycles of Gemcitabine/Docetaxel/Bevacizumab 09/2022 – 12/2022
Status post Pazopanib therapy for 7 days, including development of a “posterior reversible encephalopathy syndrome” (PRES)
Currently planned start of therapy with Trabectedin

Course:

The patient herself is not present at the teleconsultation, the consultation takes place with the patient's brother. A detailed and risk-adapted discussion followed. All questions were answered with the help of the translator. The patient's medical history has a Karnofsky index of 60%. She did not tolerate the first-line combination chemotherapy well, which was stopped due to hepatic progression. During second-line therapy with Pazopanib, the patient developed PRES. Currently, she has largely recovered from it, at least cognitively.

Procedure:

Re-staging after 3 cycles of Trabectedin.
If the disease progresses again, therapy with Caelyx (pegylated liposomal Doxorubicin) can be considered.
There is currently uncertainty regarding the presence of cerebral metastases. Re-evaluation of the submitted records, done at home, may be required.
Repeated consultation in case of need or complaint can be held at any time.

Best regards

Prof. Dr. Florin-Andrei Taran
Deputy Medical Director

This letter was written in German. The University Hospital Freiburg assumes no liability for translation errors.

Gynecology Clinic

Medical director

Prof. Dr. medical I. Juhasz-Böss

www.uniklinik-freiburg.de/frauenheilkunde

Fribourg, 06.02.2023

Tar/

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