Anastasia Zherlitsyna — timeline

Metastatic GIST (initially diagnosed as uterine leiomyosarcoma), Kyiv, Ukraine · records 2022–2026 · updated 14 Oct 2026

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Hospital discharge after the second week of imatinib

Date: 2023-05-15   Institution: Innovacia clinic, Kyiv   Type: Discharge summary
Source file (Google Drive, docs_eng/): Hospital discharge_15.05.2023.docx

Links: English translation on Google Drive [hosted copy] (Hospital discharge_15.05.2023.docx)   (Ukrainian original (on this site) · Drive backup [hosted copy])

Ministry of health of Ukraine
Medical clinic “Innovation” LLC
07352, Ukraine, Kyiv region, Vyshhorods’kyi district, Lyutizh, Vitryanoho Street
Code for the Unified State Register of Enterprises and Organizations of Ukraine 36076865

MEDICAL DOCUMENTATION
Form of primary accounting
documentation No. 028/0
APPROVED
Order of the Ministry of Health
of Ukraine of February 14, 2012
No. 110

(in the edition of the order of the Ministry of Health of Ukraine dated August 8, 2014 No. 549)

Advisory opinion of an oncologist

  1. The name of the health care facility that referred the patient for consultation

  2. Patient's name:
    Anastasia Stanislavivna Zherlitsyna

  3. Date of birth: 25.04.1976 .

  4. Specialty, last name, first name of the consulting physician:
    Oncologist Oksana Mykolaivna Latsinnikova

  5. Results of laboratory study:

  6. Results of functional, X-ray and other special studies:

  7. Specialist's conclusion (established diagnosis):

Main: Diagnosis: GIST of the stomach with secondary liver damage.

Condition after EUS-FNA of gastric biopsy (April 21, 2023), liver core biopsy (April 25, 2023), histologically - gastrointestinal stromal tumor (GIST) of the stomach, GIST metastasis in the liver (CSD).

Condition after trepan biopsy of the liver (28.08.2022 NCI). Histopathological conclusion:uterine leiomyosarcoma.

Condition after 4 cycles of chemotherapy according to the Gemcitabine+Docetaxel+Avastin protocol with progression in the liver (MRI of the abdominal cavity, pelvic organs on 14.10.2022, CT scan on 01.12.2022).

Kit, MET mutations were detected (whole genome sequencing ONCOMINE, 12.2022).

Treatment with Pazopanib from January 5 to 12, 2023, with the development of the posterior reversible encephalopathy syndrome and positive dynamics according to CT data from February 9, 2023.

Repeat liver biopsy (January 23, 2023, Oberig). Histopathological conclusion: metastasis of uterine leiomyosarcoma.

The condition after 3 cycles of chemotherapy according to the Trabectedin protocol with minimal negative dynamics according to the PET-CT data (11.04.2023): Known masses in the liver and the mass on the left, which according to the configuration rather originates from the stomach wall have slightly increased, are metabolically active. Masses in the uterus and in/near the right ovary with low metabolic activity, structurally stable. A significant difference in the activity of liver/stomach and uterine masses suggests different neoplastic processes, in particular, primarily aggressive from the stomach/GIST. The primary biopsy from 08.2022 is being reviewed in the CSD laboratory.

Associated diagnosis: Iron deficiency anemia. Type 2 diabetes mellitus, hypovitaminosis D.

Closed segmental fracture of the distal metaphysis of the left radius with displacement of fragments (11.02.2023p.)

The condition against the background of treatment with Imatinib (from 03.05.2023) with clinically pronounced positive dynamics.

  1. Recommendations:


1. Continue taking Imatinib at 400 mg/day with control of PET-CT/CT after 3 months.

2. For nausea - Zofetron 8 mg (1 tab) orally 1 - 3 times a day, the maximum daily dose - 32 mg (4 tablets per day), it is also possible to take Cerukal 10-20 mg (1-2 tablets), up to 6 tablets per day, in 2-3 receptions.

3. In the case of mucositis (redness, swelling, ulceration of the mucous membrane of the oral cavity) - start treatment of the oral cavity with oral antiseptics (Oracept, Givalex, Stomatidin), if the condition worsens - Diflucan 150 mg orally (according to agreement).

4. Adherence to the drinking regime - consumption of at least 2 - 2.5 liters of liquid per day (ReO water) (under the control of diuresis and blood pressure indicators!)

5. If the skin is dry - use fatty creams and cosmetic oils, if the conjunctiva is dry - drops "Artificial Tears" or "Hylo-Care". For dryness of the nasal mucosa - spray "Aqua-Maris" or "Humer", "Marimer", oil solutions of Chlorophyllipt, sea buckthorn oil, olive oil. Treat the mucous membrane of the nose with Synthomycin ointment 2-3 times a day for 10 days.

6. General analysis, biochemical blood analysis once a month.

7. For constipation - Duphalac 20 ml 1 time a day every day after breakfast.

8. For diarrhea, start Imodium - 2 caps. immediately, then 1 capsule after each episode of loose stools (up to 8 capsules per day).

9. In case of deterioration of well-being - phone number of the doctor on duty 0968151618

10. Eliquis 2.5 mg 2 times a day continued.

11. Control of the level of vit D3 in 1 week.

12. Follow the recommendations of the endocrinologist.

13. Hepavista - detox 1 tab 2 times a day.

14. Calcium+vit D3 (1000 mg Calcium/day) 1 month.

15. Control examination in 1 month

May 15, 2023

Doctor consultant _______________________________

/Latsinnikova Oksana Mykolayivna/

Head of polyclinic or inpatient department _______________________________